论文标题
使用生物组织模型中的信息来量化局部结构和细胞重排之间的联系
Quantifying the link between local structure and cellular rearrangements using information in models of biological tissues
论文作者
论文摘要
机器学习技术已用于量化无序玻璃形成材料中局部结构特征与局部动力活性变化之间的关系。迄今为止,这些方法已应用于标准阵列(Arrhenius和Super-Arrhenius)玻璃板,其中“软点”上的工作表明构型的线性振动响应与非线性变形的能量屏障之间的连接。在这里,我们研究了Voronoi模型,该模型从密集的上皮单层中汲取灵感,并显示出其动力放松时间的异常,亚arlhenius缩放,并且温度降低。尽管存在这些差异,但我们发现重排的可能性可能会因模型组织中的几个数量级而变化,并提取局部结构量,“柔软度”准确地预测了松弛时间的温度依赖性。我们使用信息理论措施来量化软性决定即将到来的拓扑重排的程度;我们发现,柔软度几乎捕获了可从结构中获得的重排的所有信息,并且该信息在模型的固相中很大,并且随着状态变量在流体相变化而迅速降低。
Machine learning techniques have been used to quantify the relationship between local structural features and variations in local dynamical activity in disordered glass-forming materials. To date these methods have been applied to an array of standard (Arrhenius and super-Arrhenius) glass formers, where work on "soft spots" indicates a connection between the linear vibrational response of a configuration and the energy barriers to non-linear deformations. Here we study the Voronoi model, which takes its inspiration from dense epithelial monolayers and which displays anomalous, sub-Arrhenius scaling of its dynamical relaxation time with decreasing temperature. Despite these differences, we find that the likelihood of rearrangements can vary by several orders of magnitude within the model tissue and extract a local structural quantity, "softness" that accurately predicts the temperature-dependence of the relaxation time. We use an information-theoretic measure to quantify the extent to which softness determines impending topological rearrangements; we find that softness captures nearly all of the information about rearrangements that is obtainable from structure, and that this information is large in the solid phase of the model and decreases rapidly as state variables are varied into the fluid phase.