论文标题
通过在汇合组织中波动边缘紧张产生的非单调流体
Non-monotonic fluidization generated by fluctuating edge tensions in confluent tissues
论文作者
论文摘要
在开发和稳态中，多细胞系统在其生化和机械性能中表现出空间和时间异质性。然而，尚不清楚时空异质力如何影响汇合组织的动力学和机械性能。为了解决这个问题，我们研究了上皮单层的二维细胞顶点模型的动力学行为，在存在波动的细胞 - 细胞界面张力张力的情况下，这是机械时空异质性的生物学相关来源。特别是，我们研究了张力波动对组织动力学的幅度和持久时间的影响。我们出乎意料地发现，长期扩散常数描述细胞重排的长期扩散常数非单调地取决于持续时间，而随着幅度的增加，它单调增加。我们的分析表明，在低和中间的持久性时期，张力波动驱动了顶点并促进细胞重排，而在最高持久性时，网络中的张力会慢慢发展，以至于重排变得罕见。
In development and homeostasis, multi-cellular systems exhibit spatial and temporal heterogeneity in their biochemical and mechanical properties. Nevertheless, it remains unclear how spatiotemporally heterogeneous forces affect the dynamical and mechanical properties of confluent tissue. To address this question, we study the dynamical behavior of the two-dimensional cellular vertex model for epithelial monolayers in the presence of fluctuating cell-cell interfacial tensions, which is a biologically relevant source of mechanical spatiotemporal heterogeneity. In particular, we investigate the effects of the amplitude and persistence time of fluctuating tension on the tissue dynamics. We unexpectedly find that the long-time diffusion constant describing cell rearrangements depends non-monotonically on the persistence time, while it increases monotonically as the amplitude increases. Our analysis indicates that at low and intermediate persistence times tension fluctuations drive motion of vertices and promote cell rearrangements, while at the highest persistence times the tension in the network evolves so slowly that rearrangements become rare.
