论文标题
冠状病毒COV-1和COV-2的同步附件和达尔文的进化
Synchronized Attachment and the Darwinian Evolution of Coronaviruses CoV-1 and CoV-2
论文作者
论文摘要
COV2019的发展比COV2003更危险。实验表明，结构重排大大增强了COV2019活性。我们确定了一个新的第一阶段感染的第一阶段，该阶段通过使用生物分子进化论来识别序列差异提高病毒依恋率，该感染的新第一阶段。我们发现一小群突变表明COV-2具有新功能，可以促进更强的病毒依恋并增强传染性。人类冠状病毒感染的极其危险的动态是自组织网络对关键的进化方法的一个戏剧性例子。它可能有利于非常成功的疫苗。确定的突变可用于实验测试目前的理论。
CoV2019 has evolved to be much more dangerous than CoV2003. Experiments suggest that structural rearrangements dramatically enhance CoV2019 activity. We identify a new first stage of infection which precedes structural rearrangements by using biomolecular evolutionary theory to identify sequence differences enhancing viral attachment rates. We find a small cluster of mutations which show that CoV-2 has a new feature that promotes much stronger viral attachment and enhances contagiousness. The extremely dangerous dynamics of human coronavirus infection is a dramatic example of evolutionary approach of self-organized networks to criticality. It may favor a very successful vaccine. The identified mutations can be used to test the present theory experimentally.
