论文标题
基因更喜欢细菌中的非aug起始密码子
Genes Preferring Non-AUG Start Codons in Bacteria
论文作者
论文摘要
在这里，我们通过分析完全组装基因组中的起始密码子的分布来研究细菌中的翻译调节。我们报告了36个基因（INFC，RPOC，RNPA等），显示了对进化多样的门中非aug起始密码子（“ non-aug基因”）的偏爱。大多数非AUG基因在功能上与翻译，转录或复制有关。在大肠杆菌中，这36种基本基因的百分比显着高于所有基因之间的比例。此外，这些基因的功能分布表明，可以使用非aug启动密码子来减少饥饿条件下的基因表达，这可能是通过翻译自动调节或IF3介导的调节。
Here we investigate translational regulation in bacteria by analyzing the distribution of start codons in fully assembled genomes. We report 36 genes (infC, rpoC, rnpA, etc.) showing a preference for non-AUG start codons in evolutionarily diverse phyla ("non-AUG genes"). Most of the non-AUG genes are functionally associated with translation, transcription or replication. In E. coli, the percentage of essential genes among these 36 is significantly higher than among all genes. Furthermore, the functional distribution of these genes suggests that non-AUG start codons may be used to reduce gene expression during starvation conditions, possibly through translational autoregulation or IF3-mediated regulation.
