论文标题
波形蛋白细胞骨架：当聚合物物理符合细胞生物学时
The vimentin cytoskeleton: When polymer physics meets cell biology
论文作者
论文摘要
组织的正确功能取决于细胞承受压力和保持形状的能力。该过程的核心是细胞骨架，由三个聚合物网络组成：F-肌动蛋白，微管和中间丝。中间细丝蛋白是细胞中最丰富的细胞骨架蛋白之一。然而，它们仍然是最不了解的人之一。它们的结构和功能偏离了其细胞骨架伴侣，F-肌动蛋白和微管的结构和功能。中间细丝网络表现出赋予机械弹性的扩展性，柔韧性和韧性的独特组合。波形蛋白是一种在间充质细胞中表达的中间丝蛋白。这篇评论强调了有关波形蛋白中间丝的物理生物学的令人兴奋的新结果，以及它们在使整个细胞和组织应对压力方面的作用。
The proper functions of tissues depend on the ability of cells to withstand stress and maintain shape. Central to this process is the cytoskeleton, comprised of three polymeric networks: F-actin, microtubules, and intermediate filaments. Intermediate filament proteins are among the most abundant cytoskeletal proteins in cells; yet they remain one of the least understood. Their structure and function deviate from those of their cytoskeletal partners, F-actin and microtubules. Intermediate filament networks show a unique combination of extensibility, flexibility and toughness that confers mechanical resilience to the cell. Vimentin is an intermediate filament protein expressed in mesenchymal cells. This review highlights exciting new results on the physical biology of vimentin intermediate filaments and their role in allowing whole cells and tissues to cope with stress.
