论文标题
SARS-COV-2检测高度敏感的表面等离子体共振传感器的数值分析
Numerical Analysis of a Highly Sensitive Surface Plasmon Resonance Sensor for SARS-CoV-2 Detection
论文作者
论文摘要
在本文中，我们提出了一个基于Kretschmann配置的表面等离子体共振（SPR）结构，该结构在AG上纳入了AG上的硅和Batio $ _3 $，用于实时检测严重的急性呼吸综合症冠状病毒2（SARS-COV-2），使用硫醇螺旋蛋白DNA作为Ligand。已经进行了基于转移矩阵理论以及有限差分时间域（FDTD）技术的广泛数值分析，以表征传感器响应，考虑到灵敏度，半最大值的全宽度和最小反射。与基本的Kretschmann配置相比，使用建议的SARS-COV-2检测的构建结构获得了大约7.6倍增强的灵敏度。值得注意的是，该结构比其他竞争性SPR结构提供了一致的增强，以692.28为单位的角度和波长询问。此外，我们重复了各种测定法 - 配对对的模拟，以评估已观察到适用性和稳健性能提高的范围。结果，所提出的传感器设计为高度敏感，快速，无创的生物传感提供了合适的配置，如果在实验传感方案中采用，则可以有用。
In this paper, we propose a surface plasmon resonance (SPR) structure based on Kretschmann configuration incorporating layers of Silicon and BaTiO$_3$ on top of Ag for real-time detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) using thiol tethered DNA as a ligand. Extensive numerical analysis based on transfer matrix theory as well as finite-difference time-domain (FDTD) technique has been performed to characterize the sensor response considering sensitivity, full width at half maxima, and minimum reflection. About 7.6 times enhanced sensitivity has been obtained using the proposed architecture for SARS-CoV-2 detection, compared to the basic Kretschmann configuration. Notably, the structure provides consistent enhancement over other competitive SPR structures for both angular and wavelength interrogations with a figure-of-merit of 692.28. Additionally, we repeated simulations for various ligate-ligand pairs to assess the range of applicability and robust performance improvement has been observed. As a result, the proposed sensor design provides a suitable configuration for highly sensitive, rapid, non-invasive biosensing which can be useful if adopted in experimental sensing protocols.
