论文标题
血液动力学较大的静水压力而不是较低的剪切应力加剧动脉粥样硬化
Hemodynamic Bigger Hydrostatic Pressure Instead of Lower Shear Stress Aggravates Atherosclerosis
论文作者
论文摘要
传统观点是，血流的低剪切应力加速了动脉粥样硬化。低剪切应力如何损害血管或加剧动脉粥样硬化？这是一个令人困惑的问题。此外，静脉的剪切应力类似于相对脆弱的动脉区域（RVZ），而静脉内膜增厚并不像动脉一样明显。随着血液速度的降低，小动脉中有许多地方的剪切应力，而小动脉的增厚并不像中型动脉那样明显。这些问题使我们不相信用较低的剪切应力来解释动脉粥样硬化。根据Bernoulli流体方程（P+1/2 \ r {HO} V^2+\ r {HO} GH =常数），在充满流动血液的封闭管道中，静水压力与第二个血液速度的第二功率成反比。在此处的流体微簇的每单位质量的任何点上，1/2 \ r {ho} v^2的还原将转换为P。因此，静水压力（P）在非常短的距离或相同的动脉转移中与V^2成反比。当血液微聚类在非常短的距离或相同的动脉横向流动时，先前的研究并未考虑1/2 \ r {ho} v^2和P之间的转化率，因此，低剪切应力加剧了动脉粥样硬化是一种外观，而这些区域的本质是，这些区域较小的血液速度较小，具有更大的水压压力，可以使水平粘重，从而使Atherossosis aTherossosis aTherossosis。这完美地解释了动脉粥样硬化的诱人部位。
The traditional view is that low shear stress of blood flow accelerates atherosclerosis. How does a low shear stress damage the vessel or aggravate atherosclerosis? It is a puzzling question. Furthermore, shear stress of veins is similar to that of Relatively Vulnerable Zones (RVZ) of arteries, while intimal thickening of veins is not obvious as the arteries. There are many places in arterioles with lower shear stress as the decrease of blood velocity, while the thickening of arterioles is not as obvious as that of the medium-sized arteries. These issues make it unconvincing for us to explain atherogenesis with lower shear stress. According to Bernoulli fluid equation (P+1/2\r{ho}v^2+\r{ho}gh=constant), in a closed pipe full of flowing blood, at the same height, the hydrostatic pressure is inversely proportional to the second power of blood velocity. At any point of per unit mass of fluid micro cluster here, the reduction of 1/2\r{ho}v^2 would be converted into P. Therefore, hydrostatic pressure(P) is inversely proportional to v^2 in a very short distance or in the same transection of the artery. When blood micro cluster flows over a very short distance or the same transection of the artery, previous studies did not consider the conversion between 1/2\r{ho}v^2 and P. Therefore, low shear stress aggravates atherosclerosis is an appearance, and the essence is that these areas with smaller blood velocity have much bigger hydrostatic pressure, which aggravates atherosclerosis. This perfectly explains the predisposing sites of atherosclerosis.
