论文标题
葡萄糖胰岛素数学模型，用于药物的综合作用和2型糖尿病患者的生命样式
Glucose-insulin mathematical model for the combined effect of medications and life style of Type 2 diabetic patients
论文作者
论文摘要
本文的目的是提出一个新的数学模型，以对不同治疗和生活方式对2型糖尿病（T2D）患者的葡萄糖 - 胰岛素动力学的综合作用。该模型在评估或设计T2D患者的治疗计划的同时考虑了体育锻炼，压力，进餐和药物的可能性。该模型是通过结合和修改文献中一些可用模型来提出的。进行了模拟以进行修改，以显示模型如何通过T2D患者的文献确认。此外，还提供了讨论，以证明该模型用于评估治疗计划的能力以及用于鲁棒胰岛素剂量引导算法的设计。还提供了该模型的开源代码。
The goal of this paper is to propose a new mathematical model for the combined effect of different treatments and lifestyles on the glucose-insulin dynamics of Type 2 diabetes (T2D) patients. The model gives the possibility to take into consideration physical activity, stress, meals, and medications while evaluating or designing treatment plans for T2D patients. The model is proposed by combining and modifying some of the available models in the literature. Simulations were performed for the modifications to show how the model confirm with literature on T2D patients. Additionally, a discussion is provided to demonstrate the ability of the model to be used in the assessment of treatment plans and in the design for robust insulin dose guidance algorithms. An open source code for the model is additionally provided.
