论文标题
SARS-COV-2和miRNA样抑制功率
SARS-CoV-2 and miRNA-like inhibition power
论文作者
论文摘要
（1）背景：RNA病毒，尤其是冠状病毒不仅可以通过构建自己的蛋白质，而且可以通过扰动细胞代谢来作用。我们显示了SARS-COV-2对例如血红蛋白和I型干扰素合成的抑制作用的可能性，因此，如临床医生所述，在重要器官中高度扰动氧分布以及免疫反应。 （2）方法：我们比较SARS-COV-2蛋白S和RNA依赖性RNA聚合酶基因的RNA子序列与β-珠蛋白和I型干扰素的mRNA序列； （3）结果：SARS-COV-2基因组的RNA子序列长于八个核苷酸可以杂交β-珠蛋白和I型干扰素的mRNA的子序列； （4）结论：除了病毒蛋白的产生，COVID-19可能会影响诸如宿主氧运输和免疫反应之类的重要过程。
(1) Background: RNA viruses and especially coronaviruses could act inside host cells not only by building their own proteins, but also by perturbing the cell metabolism. We show the possibility of miRNA-like inhibitions by the SARS-CoV-2 concerning for example the hemoglobin and type I interferons syntheses, hence highly perturbing oxygen distribution in vital organs and immune response as described by clinicians; (2) Methods: We compare RNA subsequences of SARS-CoV-2 protein S and RNA-dependent RNA polymerase genes to mRNA sequences of beta-globin and type I interferons; (3) Results: RNA subsequences longer than eight nucleotides from SARS-CoV-2 genome could hybridize subsequences of the mRNA of beta-globin and of type I interferons; (4) Conclusions: Beyond viral protein production, Covid-19 might affect vital processes like host oxygen transport and immune response.
