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Nonlinear estimation in robotics and vision is typically plagued with outliers due to wrong data association, or to incorrect detections from signal processing and machine learning methods. This paper introduces two unifying formulations for outlier-robust estimation, Generalized Maximum Consensus (G-MC) and Generalized Truncated Least Squares (G-TLS), and investigates fundamental limits, practical algorithms, and applications. Our first contribution is a proof that outlier-robust estimation is inapproximable: in the worst case, it is impossible to (even approximately) find the set of outliers, even with slower-than-polynomial-time algorithms (particularly, algorithms running in quasi-polynomial time). As a second contribution, we review and extend two general-purpose algorithms. The first, Adaptive Trimming (ADAPT), is combinatorial, and is suitable for G-MC; the second, Graduated Non-Convexity (GNC), is based on homotopy methods, and is suitable for G-TLS. We extend ADAPT and GNC to the case where the user does not have prior knowledge of the inlier-noise statistics (or the statistics may vary over time) and is unable to guess a reasonable threshold to separate inliers from outliers (as the one commonly used in RANSAC). We propose the first minimally tuned algorithms for outlier rejection, that dynamically decide how to separate inliers from outliers. Our third contribution is an evaluation of the proposed algorithms on robot perception problems: mesh registration, image-based object detection (shape alignment), and pose graph optimization. ADAPT and GNC execute in real-time, are deterministic, outperform RANSAC, and are robust up to 80-90% outliers. Their minimally tuned versions also compare favorably with the state of the art, even though they do not rely on a noise bound for the inliers.