论文标题
基于循环流量调制的生物分子系统反馈控制的能量建模
Energy-based Modelling of the Feedback Control of Biomolecular Systems with Cyclic Flow Modulation
论文作者
论文摘要
基于能量的建模将工程洞察力带入了对生物分子系统的理解。它显示了良好的控制工程概念，例如循环增益，是由能量反馈循环产生的，因此可以控制工程洞察力。特别是，引入了一种新颖的方法，以允许基于转移函数的经典线性控制的方法用于通过网络热力学建模的反馈系统，从而通过控制系统分析建模的基于网络热力学的反馈系统。使用一类具有激活和抑制作用的代谢循环的概念来说明该方法。
Energy-based modelling brings engineering insight to the understanding of biomolecular systems. It is shown how well-established control engineering concepts, such as loop-gain, arise from energy feedback loops and are therefore amenable to control engineering insight. In particular, a novel method is introduced to allow the transfer function based approach of classical linear control to be utilised in the analysis of feedback systems modelled by network thermodynamics and thus amalgamate energy-based modelling with control systems analysis. The approach is illustrated using a class of metabolic cycles with activation and inhibition leading the concept of Cyclic Flow Modulation.
