论文标题
超极化$^{13} $ c成像的3D杂交螺旋序列
A 3D-Hybrid-Shot Spiral Sequence for Hyperpolarized $^{13}$C Imaging
论文作者
论文摘要
目的：超极化成像实验对高空间，时间和光谱分辨率的要求相互矛盾。光谱空间RF激发已被证明是一种用于超极化成像的有吸引力的磁化效率方法，但最佳读数策略尚不清楚。 方法：在这项工作中，我们提出了一种新型的3D混合螺旋序列，该序列具有两个恒定密度区域，可回顾性重建高空间或高时间分辨率图像事后事后发生的高空分辨率图像（自适应时空时空成像），允许在获取和重建中更大的灵活性。 结果：我们已经通过模拟和临床前扫描仪实现了此序列，以证明其在1H幻影和体内超极化13c丙酮酸的可行性。结论：该序列构成了获取超极化成像数据集的一种有吸引力的方法，从而提供了适应性时空成像，以减轻空间和时间分辨率的冲突，具有临床翻译的巨大潜力。
Purpose: Hyperpolarized imaging experiments have conflicting requirements of high spatial, temporal, and spectral resolution. Spectral-Spatial RF excitation has been shown to form an attractive magnetization-efficient method for hyperpolarized imaging, but the optimum readout strategy is not yet known. Methods: In this work we propose a novel 3D hybrid-shot spiral sequence which features two constant density regions that permit the retrospective reconstruction of either high spatial or high temporal resolution images post hoc, (adaptive spatiotemporal imaging) allowing greater flexibility in acquisition and reconstruction. Results: We have implemented this sequence, both via simulation and on a pre-clinical scanner, to demonstrate its feasibility, in both a 1H phantom and with hyperpolarized 13C pyruvate in vivo. Conclusion: This sequence forms an attractive method for acquiring hyperpolarized imaging datasets, providing adaptive spatiotemporal imaging to ameliorate the conflict of spatial and temporal resolution, with significant potential for clinical translation.
