论文标题
用软脂囊泡包裹微粒
Wrapping of Microparticles by Floppy Lipid Vesicles
论文作者
论文摘要
脂质膜，定义活细胞及其许多子室的屏障与各种纳米和微米大小的物体结合。在具有强粘合力的情况下，膜可以强烈变形和包裹颗粒，这是跨越膜的重要步骤，以进行各种健康和疾病相关的过程。大量的理论和数值工作重点是识别基本包装的物理特性。使用具有可调粘合力的微米大小胶体颗粒和巨型Unilamelar脂质囊泡的模型系统，我们测量包装相图并与理论模型进行定量比较。我们的数据与膜粒子相互作用的模型一致，该模型考虑了单位面积的粘合能，膜弯曲刚度，粒径和囊泡半径。
Lipid membranes, the barrier defining living cells and many of their sub-compartments, bind to a wide variety of nano- and micro-meter sized objects. In the presence of strong adhesive forces, membranes can strongly deform and wrap the particles, an essential step in crossing the membrane for a variety of health and disease-related processes. A large body of theoretical and numerical work has focused on identifying the physical properties that underly wrapping. Using a model system of micron-sized colloidal particles and giant unilamellar lipid vesicles with tunable adhesive forces, we measure a wrapping phase diagram and make quantitative comparisons to theoretical models. Our data is consistent with a model of membrane-particle interactions accounting for the adhesive energy per unit area, membrane bending rigidity, particle size, and vesicle radius.
