论文标题
阻碍负载促使聚集配置，从
Hindering loads prompt clustered configurations that enhance stability during cargo transport by multiple Kinesin-1
论文作者
论文摘要
细胞内货物的运输通常是由在不同条件下在混乱环境中起作用的分子电动机团队介导的。我们表明，电动机具有独特的稳态行为，可实现强大的运输方式。在降低的ATP浓度下，多运动配置优于单电机。较高的负载力驱动电动机聚集，但是很高的负载迫使它们以一旦负载消退，以促进立即货物移动的方式分开。这些推论以分析保证的支持，为分子电动机在运输细胞内货物采用的协调策略提供了独特的见解。
Transport of intracellular cargo is often mediated by teams of molecular motors that function in a chaotic environment under varying conditions. We show that the motors have unique steady state behavior which enables transport modalities that are robust. Under reduced ATP concentrations, multi-motor configurations are preferred over single motors. Higher load force drives motors to cluster, but very high loads compel them to separate in a manner that promotes immediate cargo movement once the load subsides. These inferences, backed by analytical guarantees, provide unique insights into the coordination strategies adopted by molecular motors to transport intracellular cargo.
