论文标题
电荷模式不匹配和强烈的排除体积相互作用，促进了类似细胞器的冷凝物中多聚糖物种的子分会化。
Subcompartmentalization of polyampholyte species in organelle-like condensates is promoted by charge pattern mismatch and strong excluded-volume interaction
论文作者
论文摘要
序列特异性蛋白（IDP）物种的序列特异性相位分离的多型聚体场理论和显式链分子动力学模型始终表明，大量聚合物排除了大量的体积，并且不匹配IDP序列电荷模式可以在音乐会中起作用，但不能隔离，而不是在condensation中隔离。这一发现揭示了在随机的“模糊”分子识别机制中的能量几何相互作用，该机制可能促进膜无细胞器的子分会化。
Polyampholyte field theory and explicit-chain molecular dynamics models of sequence-specific phase separation of a system with two intrinsically disordered protein (IDP) species indicate consistently that a substantial polymer excluded volume and a significant mismatch of the IDP sequence charge patterns can act in concert, but not in isolation, to demix the two IDP species upon condensation. This finding reveals an energetic-geometric interplay in a stochastic, "fuzzy" molecular recognition mechanism that may facilitate subcompartmentalization of membraneless organelles.
