论文标题
聚合物通过三维双纳米系统逃脱
Polymer escape through a three dimensional Double-Nanopore System
论文作者
论文摘要
我们使用理想化的双纳米孔（DNP）几何形状研究双链DNA（DSDNA）的逃生动力学，使用布朗动力学（BD）模拟，受到两个相等和相反的力（拔河）。除了在孔之间施加的几何限制在孔之间的dsDNA节段上外，在每个孔隙中存在拔河力的存在导致孔之间链段的局部链刚度的变化，从而增加了孔之间的整体刚度。我们使用BD仿真结果来了解固有链的刚度和拖曳力如何通过监视纳米孔中的单个单体$ W（m）$的本地链持续时间$ \ ell_p $来影响逃生动力学，以及逃逸时间$ \ langle the \ langle fangleτ\ rangleτ\ rangle $和其分布的链长度依赖性。最后，我们概括了无偏的单纳米孔易位的缩放理论，用于在存在拖曳力的情况下通过DNP通过DNP逃脱的完全柔性链。 We establish that the stiffness dependent part of the escape time is approximately independent of the translocation mechanism so that $\langle τ\rangle \sim \ell_p^{2/D+2}$, and therefore the generalized escape time for a semi-flexible chain can be written as $\langle τ\rangle = AN^α\ell_p^{2/D+2}$.我们使用BD仿真结果比较缩放理论的预测。通过缩放分析补充的我们的数值研究为设计新实验提供了基本见解，其中dsDNA在一系列石墨烯纳米孔中缓慢移动。
We study escape dynamics of a double-stranded DNA (dsDNA) through an idealized double nanopore (DNP) geometry subject to two equal and opposite forces (tug-of-war) using Brownian dynamics (BD) simulation. In addition to the geometrical restrictions imposed on the cocaptured dsDNA segment in between the pores, the presence of tug-of-war forces at each pore results in a variation of the local chain stiffness for the segment of the chain in between the pores which increases the overall stiffness of the chain. We use BD simulation results to understand how the intrinsic chain stiffness and the TOW forces affect the escape dynamics by monitoring the local chain persistence length $\ell_p$, the residence time of the individual monomers $W(m)$ in the nanopores, and the chain length dependence of the escape time $\langle τ\rangle$ and its distribution. Finally, we generalize the scaling theory for the unbiased single nanopore translocation for a fully flexible chain for the escape of a semi-flexible chain through a DNP in presence of TOW forces. We establish that the stiffness dependent part of the escape time is approximately independent of the translocation mechanism so that $\langle τ\rangle \sim \ell_p^{2/D+2}$, and therefore the generalized escape time for a semi-flexible chain can be written as $\langle τ\rangle = AN^α\ell_p^{2/D+2}$. We use BD simulation results to compare the predictions of the scaling theory. Our numerical studies supplemented by scaling analysis provide fundamental insights to design new experiments where a dsDNA moves slowly through a series of graphene nanopores.
