论文标题
从生物物理到集成与火建模
From biophysical to integrate-and-fire modelling
论文作者
论文摘要
本文提出了一种方法，以从任意详细的单室生物物理模型中提取低维整合和传火模型。该方法旨在将生物物理模型中最大电导参数的调节与提出的集成和传火模型中的参数调制。该方法在两个有据可查的细胞神经调节示例中说明了：I型和II型兴奋性之间的过渡以及尖峰和爆发之间的过渡。
This paper proposes a methodology to extract a low-dimensional integrate-and-fire model from an arbitrarily detailed single-compartment biophysical model. The method aims at relating the modulation of maximal conductance parameters in the biophysical model to the modulation of parameters in the proposed integrate-and-fire model. The approach is illustrated on two well-documented examples of cellular neuromodulation: the transition between Type I and Type II excitability and the transition between spiking and bursting.
