论文标题
探测fMRI的大脑连通性和活动调节期间的活动变化。
Probing fMRI brain connectivity and activity changes during emotion regulation by EEG neurofeedback
论文作者
论文摘要
神经反馈是一种无创的脑训练，具有长期的医学和非医疗应用。尽管使用神经反馈进行了几项情绪调节研究，但仍需要进一步研究以了解该过程中涉及的大脑区域的相互作用。我们通过自传记忆使用修改后的诱导幸福的任务来同时使用fMRI实现EEG神经反馈，以上调积极的情绪。结果表明，在实验组中，前额叶，枕骨，顶叶和边缘区域的活性增加，前额叶，顶叶，边缘系统和岛岛之间的功能连通性提高。通过比较实验组内以及实验组和对照组之间的不同实验条件的功能连通性来确定新的连通性链接。拟议的多模式方法量化了在前额叶，顶，顶叶，limbic和Insula区域之间/之间的情绪调节期间，在情绪调节过程中，在情绪调节过程中，在情绪调节过程中，大脑活动的变化（增加了1.9％）和连通性（用于多次比较的FDR校正，Q = 0.05）。心理测量评估证实了神经反馈的正情绪状态和负面情绪状态的显着变化，实验组的P值小于0.002。这项研究量化了脑电图神经反馈对改变情绪调节所有大脑区域的功能连通性的影响。对于参与情绪调节的大脑区域，我们发现由于实验组的神经反馈而导致的大胆和功能连通性增加，但在对照组中未观察到学习效果。结果揭示了EEG神经反馈对情绪调节的神经生物学底物，并将神经反馈的效果和自传记忆的回忆分开。
Neurofeedback is a non-invasive brain training with long-term medical and non-medical applications. Despite the existence of several emotion regulation studies using neurofeedback, further investigation is needed to understand interactions of the brain regions involved in the process. We implemented EEG neurofeedback with simultaneous fMRI using a modified happiness-inducing task through autobiographical memories to upregulate positive emotion. The results showed increased activity of prefrontal, occipital, parietal, and limbic regions and increased functional connectivity between prefrontal, parietal, limbic system, and insula in the experimental group. New connectivity links were identified by comparing the functional connectivity of different experimental conditions within the experimental group and between the experimental and control groups. The proposed multimodal approach quantified the changes in the brain activity (up to 1.9% increase) and connectivity (FDR-corrected for multiple comparison, q = 0.05) during emotion regulation in/between prefrontal, parietal, limbic, and insula regions. Psychometric assessments confirmed significant changes in positive and negative mood states by neurofeedback with a p-value smaller than 0.002 in the experimental group. This study quantifies the effects of EEG neurofeedback in changing functional connectivity of all brain regions involved in emotion regulation. For the brain regions involved in emotion regulation, we found significant BOLD and functional connectivity increases due to neurofeedback in the experimental group but no learning effect was observed in the control group. The results reveal the neurobiological substrate of emotion regulation by the EEG neurofeedback and separate the effect of the neurofeedback and the recall of the autobiographical memories.
