论文标题
哺乳动物大脑的常见细胞类型命名法：一种系统的，可扩展的惯例
Common Cell type Nomenclature for the mammalian brain: A systematic, extensible convention
论文作者
论文摘要
单细胞RNA测序技术的进步导致了多个器官和生物的细胞类型定义爆炸。尽管出现了数据和元数据摄入标准，但细胞类型的组织基本上留给了个别研究人员，导致分类法之间的命名法和有限的一致性变化。为了促进跨数据库比较，艾伦研究所创建了跨研究跨不同基因组构建基因转录本在质量上相似的研究中匹配和跟踪细胞类型的共同细胞类型命名法（CCN）。 CCN可以很容易地应用于新的或已建立的分类法上，并在此应用于从多种可量化模式中得出的各种细胞类型数据集。 CCN促进了在哺乳动物皮层中分配准确而灵活的细胞类型名称，这是朝着社区范围内努力组织的一步，以组织多种数据驱动的信息，与任何生物体的细胞类型分类法有关。
The advancement of single cell RNA-sequencing technologies has led to an explosion of cell type definitions across multiple organs and organisms. While standards for data and metadata intake are arising, organization of cell types has largely been left to individual investigators, resulting in widely varying nomenclature and limited alignment between taxonomies. To facilitate cross-dataset comparison, the Allen Institute created the Common Cell type Nomenclature (CCN) for matching and tracking cell types across studies that is qualitatively similar to gene transcript management across different genome builds. The CCN can be readily applied to new or established taxonomies and was applied herein to diverse cell type datasets derived from multiple quantifiable modalities. The CCN facilitates assigning accurate yet flexible cell type names in the mammalian cortex as a step towards community-wide efforts to organize multi-source, data-driven information related to cell type taxonomies from any organism.
