论文标题
血氧饱和度的入耳式测量：检测COVID-19中延迟威胁生命的低氧血症所需的门诊工具
In-Ear Measurement of Blood Oxygen Saturation: An Ambulatory Tool Needed To Detect The Delayed Life-Threatening Hypoxaemia in COVID-19
论文作者
论文摘要
血氧饱和度的非侵入性卧床估计已成为在Covid-19的延迟感染后阶段检测低氧血症的重要临床要求，在没有主观呼吸困难的情况下，可能发生危险的缺氧。这种直接的临床驱动力，再加上对更个性化的健康数据的一般寻求，这意味着毛细血管氧饱和度（SPO2）的脉搏血氧仪测量可能会在不久的将来扩展到可穿戴健康技术的临床和消费者市场。在这项研究中，我们着手确定从耳道的SPO2测量的可行性，作为长期监测的便捷部位，并与正确的食指进行全面比较 - 常规的临床测量位点。在静止的SPO2估计中，我们发现两个测量位点之间的根平方差为1.47％，右耳管中的平均差异为0.23％。通过在呼吸期间同时记录右耳管和食指的脉搏血氧饱和度，我们观察到耳朵和手指之间的响应时间有了显着改善，其平均为12.4秒，所有受试者的范围为4.2-24.2秒。还探讨了影响此响应时间的因素，称为SPO2延迟，例如受试者的性别。此外，我们研究了耳道血氧饱和度测量值的潜在弊端，即较低的光杀解物振幅，并提出了减轻这种劣势的方法。这些结果与先前发现的益处（例如对温度的鲁棒性）一起介绍，这使得从耳道中测量SPO2的理由既方便又优于常规的手指测量位点，以在临床和日常生活环境中进行连续的非侵入性长期监测。
Non-invasive ambulatory estimation of blood oxygen saturation has emerged as an important clinical requirement to detect hypoxemia in the delayed post-infective phase of COVID-19, where dangerous hypoxia may occur in the absence of subjective breathlessness. This immediate clinical driver, combined with the general quest for more personalised health data, means that pulse oximetry measurement of capillary oxygen saturation (SpO2) will likely expand into both the clinical and consumer market of wearable health technology in the near future. In this study, we set out to establish the feasibility of SpO2 measurement from the ear canal as a convenient site for long term monitoring, and perform a comprehensive comparison with the right index finger - the conventional clinical measurement site. During resting SpO2 estimation, we found a root mean square difference of 1.47% between the two measurement sites, with a mean difference of 0.23% higher SpO2 in the right ear canal. Through the simultaneous recording of pulse oximetry from both the right ear canal and index finger during breath holds, we observe a substantial improvement in response time between the ear and finger that has a mean of 12.4 seconds and a range of 4.2 - 24.2 seconds across all subjects. Factors which influence this response time, termed SpO2 delay, such as the sex of a subject are also explored. Furthermore, we examine the potential downsides of ear canal blood oxygen saturation measurement, namely the lower photoplethysmogram amplitude, and suggest ways to mitigate this disadvantage. These results are presented in conjunction with previously discovered benefits such as robustness to temperature, making the case for measurement of SpO2 from the ear canal being both convenient and superior to conventional finger measurement sites for continuous non-intrusive long term monitoring in both clinical and everyday-life settings.
