论文标题
无投影仪的光学属性映射的Speckle Inlumination SFDI
Speckle illumination SFDI for projector-free optical property mapping
论文作者
论文摘要
空间频域成像可以在广泛的视野上绘制组织散射和吸收特性，使其可用于临床应用，例如伤口评估和手术指导。此技术以前需要投影完全示范的照明模式。在这里，我们表明，随机和未知的斑点照明可用于在已知的空间频率下采样组织的调制传递函数，从而可以使用简单的激光二极管照明对光学性质进行定量映射。我们为每个像素的局部功率频谱密度计算低空间和高空间频率响应参数，并在组织幻像，体内人的手和体内猪食管中使用可准确估算的吸收和散射系数。由于可以在较大的景深和视野中生成斑点图案，并具有简单的相干照明，因此该方法可以在包括内窥镜检查在内的新形式因子和应用中启用光属性映射。
Spatial Frequency Domain Imaging can map tissue scattering and absorption properties over a wide field of view, making it useful for clinical applications such as wound assessment and surgical guidance. This technique has previously required the projection of fully-characterized illumination patterns. Here, we show that random and unknown speckle illumination can be used to sample the modulation transfer function of tissues at known spatial frequencies, allowing the quantitative mapping of optical properties with simple laser diode illumination. We compute low- and high-spatial frequency response parameters from the local power spectral density for each pixel and use a look-up-table to accurately estimate absorption and scattering coefficients in tissue phantoms, in vivo human hand, and ex vivo swine esophagus. Because speckle patterns can be generated over a large depth of field and field of view with simple coherent illumination, this approach may enable optical property mapping in new form-factors and applications, including endoscopy.
