论文标题
从$ {}^57 $ fe富集$β$ thalassaemia鼠标模型的内脏器官和大脑中的铁复合物的研究。
Study of iron complexes in visceral organs and brain from a ${}^57$Fe enriched $β$-thalassaemia mouse model via Mössbauer Spectroscopy
论文作者
论文摘要
$ {}^57 $ fe富集的野生型和杂合$β$β$ - thalassapemic小鼠在1、3、6和9个月大时通过MössbauerSpectrroscopopy研究了心脏，肾脏，肝脏，脾脏和大脑。发现心脏中的铁蛋白样铁沉积和丘脑血症小鼠的大脑略有增加，而在肾脏，肝脏和脾脏中发现了大量的铁蛋白样铁。在器官中发现的铁蛋白样双双体可以进一步分成两个子两倍，代表铁蛋白矿物核的内部和表面结构。在所有小鼠的心脏和大脑中以及野生型动物的肾脏中发现表面铁部位占主导地位。富含内部铁的铁蛋白主要在丘脑血症小鼠的肾脏以及肝脏和脾脏中。在所有丘脑血液样品中，内部到表面的铁位点的比率都升高，表明除铁蛋白量外，该疾病还会影响铁蛋白矿物质核心结构。
The hearts, kidneys, livers, spleens and brains of ${}^57$Fe enriched wild-type and heterozygous $β$-thalassaemic mice at 1, 3, 6 and 9 months of age were studied by means of Mössbauer Spectroscopy at 80K. Ferritin-like iron depositions in the heart and the brain of the thalassaemic mice were found to be slightly increased while significant amounts of Ferritin-like iron were found in the kidneys, liver and spleen. The ferritin-like iron doublet, found in the organs, could be further separated into two sub-doublets representing the inner and surface structures of ferritin mineral core. Surface iron sites were found to be predominant in the hearts and brains of all mice and in the kidneys of the wild-type animals. Ferritin rich in inner iron sites was predominant in the kidneys of the thalassaemic mice, as well as in the livers and in the spleens. The inner-to-surface iron sites ratio was elevated in all thalassaemic samples indicating that besides ferritin amount, the disease can also affect ferritin mineral core structure.
