论文标题
响应两个刺激的细菌趋化性的数学描述
A Mathematical Description of Bacterial Chemotaxis in Response to Two Stimuli
论文作者
论文摘要
在复杂的环境中，细菌通常会暴露于多种刺激中，其有效的趋化性决策对于在其天然环境中生存和生长至关重要。细菌对环境刺激的反应取决于其相应化学感受器的比率。通过纳入单个细胞的信号机械，我们分析了大肠杆菌细菌的集体运动，这些人群对两种刺激，主要是丝氨酸和甲基 - 天冬氨酸（MASEP），在一个维度和二维环境中，这是在Y. kalinin ot an y. kalinin eT中的启发。 192（7）：1796-1800，2010。在合适的条件下，我们表明，如果单个细胞的主要化学感受器的比率（即焦油/TSR）小于特定阈值，则细菌向丝氨酸的梯度移动，并且该比率大于阈值，则大量的细菌朝着测量值的梯度移动。最后，我们使用基于蒙特卡洛药物的模拟研究了该理论，并验证我们的结果在质量上与Y. Kalinin等人的实验结果非常吻合。 （2010）。
Bacteria are often exposed to multiple stimuli in complex environments, and their efficient chemotactic decisions are critical to survive and grow in their native environments. Bacterial responses to the environmental stimuli depend on the ratio of their corresponding chemoreceptors. By incorporating the signaling machinery of individual cells, we analyze the collective motion of a population of Escherichia coli bacteria in response to two stimuli, mainly serine and methyl-aspartate (MeAsp), in a one-dimensional and a two-dimensional environment, which is inspired by experimental results in Y. Kalinin et al., J. Bacteriol. 192(7):1796-1800, 2010. Under suitable conditions, we show that if the ratio of the main chemoreceptors of individual cells, namely Tar/Tsr is less than a specific threshold, the bacteria move to the gradient of serine, and if the ratio is greater than the threshold, the group of bacteria move toward the gradient of MeAsp. Finally, we examine the theory with Monte-Carlo agent-based simulations, and verify that our results qualitatively agree well with the experimental results in Y. Kalinin et al. (2010).
