论文标题
用双态模型对细胞爬行策略进行建模：从变形虫到扇形细胞运动
Modeling cell crawling strategies with a bistable model: From amoeboid to fan-shaped cell motion
论文作者
论文摘要
真核细胞运动涉及生化成分和机械过程之间相互作用的复杂网络。该细胞采用该网络来极化和诱导形状变化，从而导致膜突起和缩回，最终导致整个细胞体的运动。细胞极化的非线性反应扩散模型，嘈杂的双重动力学以及细胞形状的动态相场的组合使我们能够捕获该复杂系统的关键特征，以研究几种运动性场景，包括变形虫和扇形形式，以及具有不同位移机制的中间状态。我们将模型的数值模拟与在不同的发育条件下的Motile {\ IT Dictyostelium distyostelium distecone {\ dice dice dice dice的数值模拟进行了比较。确定并讨论了确定不同运动状态的数学模型的主要参数。
Eukaryotic cell motility involves a complex network of interactions between biochemical components and mechanical processes. The cell employs this network to polarize and induce shape changes that give rise to membrane protrusions and retractions, ultimately leading to locomotion of the entire cell body. The combination of a nonlinear reaction-diffusion model of cell polarization, noisy bistable kinetics, and a dynamic phase field for the cell shape permits us to capture the key features of this complex system to investigate several motility scenarios, including amoeboid and fan-shaped forms as well as intermediate states with distinct displacement mechanisms. We compare the numerical simulations of our model to live cell imaging experiments of motile {\it Dictyostelium discoideum} cells under different developmental conditions. The dominant parameters of the mathematical model that determine the different motility regimes are identified and discussed.
