论文标题
红茶在减轻无机砷诱导的癌症中的免疫调节作用
Immunomodulatory role of black tea in the mitigation of cancer induced by inorganic arsenic
论文作者
论文摘要
我们在致癌剂，免疫神经剂（IM）和免疫细胞的可变涌入（包括相关相互作用）的影响下，对肿瘤和正常细胞生长进行了模型分析。肿瘤的生长是由无机砷等致癌物促进的，而此处考虑的是红茶（Camellia sinesnsis）。观察到与恒定流入模型相比，具有可变的免疫细胞流入的模型具有相当大的优势，虽然肿瘤细胞群得到了极大的减轻，但正常细胞群仍保持高于健康水平。正常细胞和肿瘤细胞的演变是根据所提出的模型计算的，并通过分析研究了其局部稳定性。进行数值模拟以研究长期动态，并对各种因素的影响进行估计。这有助于制定缓解肿瘤的均衡策略，而无需使用通常具有强大副作用的化学治疗药物。
We present a model analysis of the tumor and normal cell growth under the influence of a carcinogenic agent, an immunomdulator (IM) and variable influx of immune cells including relevant interactions. The tumor growth is facilitated by carcinogens such as inorganic arsenic while the IM considered here is black tea (Camellia sinesnsis). The model with variable influx of immune cells is observed to have considerable advantage over the constant influx model, and while the tumor cell population is greatly mitigated, normal cell population remains above healthy levels. The evolution of normal and tumor cells are computed from the proposed model and their local stabilities are investigated analytically. Numerical simulations are performed to study the long term dynamics and an estimation of the effects of various factors is made. This helps in developing a balanced strategy for tumor mitigation without the use of chemotherapeutic drugs that usually have strong side-effects.
