论文标题
在微生物屏障上流动的胶体微球的快速积累
Rapid accumulation of colloidal microspheres flowing over microfabricated barriers
论文作者
论文摘要
粒子在流过过去的收缩时的积累是在各种系统中观察到的一种普遍存在的现象。一些常见的例子是盐晶孔孔附近的盐晶体，堵塞系统的堵塞，运输中的僵局等。用于对照研究，通常在微流体通道中检查积累事件为堵塞过程。到目前为止，实验研究已经提供了各种物理见解，但是，它们无法解决与人类健康相关的常见积累事件，例如牙齿和动脉斑块。我们通过在微流体环境中的微结构屏障上流动胶体微球来模拟动脉斑块，例如积累事件。我们的实验揭示了静电，接触和流体动力在促进斑块样堆积事件中的作用。相互作用表面之间的debye长度（静电排斥）减小了两个阶，仅导致累积增加。相比之下，粗糙度的增加3倍，导致积累的急剧上升。
Accumulation of particles while flowing past constrictions is a ubiquitous phenomenon observed in diverse systems. Some of the common examples are jamming of salt crystals near the orifice of salt shakers, clogging of filter systems, gridlock in traffics etc. For controlled studies, accumulation events are often examined as clogging process in microfluidic channels. Experimental studies thus far have provided with various physical insights, however, they fail to address commonly encountered accumulation events relevant to human health such as dental and arterial plaques. We simulate arterial plaque like accumulation events by flowing colloidal microspheres over micro-structured barriers in microfluidic environment. Our experiments reveal the role of electrostatic, contact and hydrodynamic forces in facilitating plaque-like build up events. A decrease in Debye length (electrostatic repulsion) between interacting surface by two orders leads to only a minor increase in accumulation. In contrast, an increase in the roughness by 3 times results in dramatic rise of accumulation.
