论文标题
形态发生和比例生长:与扩散偶联的表面生长的有限元研究
Morphogenesis and proportionate growth: A finite element investigation of surface growth with coupled diffusion
论文作者
论文摘要
建模自然系统中形态的自发演变及其通过按比例增长进行保存仍然是一个主要的科学挑战。但是,可以想象,如果考虑到其功能的生长和耦合动力学定律的考虑,则最小的理论模型可能会表现出相似的生长行为。表面生长的无处不在,这是一种在人体边界上添加或去除材料的机制,它促使了理论模型的发展,该模型可以捕获支配它的扩散耦合动力学。但是,由于它们的复杂性,这些模型的应用仅限于简化的几何形状。在本文中,我们通过开发有限的元素框架来研究这些复杂性,以研究在均匀和平坦底物上形成的有限体的扩散偶联生长和形态发生。我们发现,在这种简化的生长环境中,不断发展的身体表现出一系列不同的生长阶段,这些阶段让人联想到天然系统,并且自发地出现而没有任何外部强加的调节或协调。这项工作中开发的计算框架可以作为能够考虑任意几何环境增长的未来模型的基础,并可以阐明在自然世界中策划生长和形态发生的基本物理定律。
Modeling the spontaneous evolution of morphology in natural systems and its preservation by proportionate growth remains a major scientific challenge. Yet, it is conceivable that if the basic mechanisms of growth and the coupled kinetic laws that orchestrate their function are accounted for, a minimal theoretical model may exhibit similar growth behaviors. The ubiquity of surface growth, a mechanism by which material is added or removed on the boundaries of the body, has motivated the development of theoretical models, which can capture the diffusion-coupled kinetics that govern it. However, due to their complexity, application of these models has been limited to simplified geometries. In this paper, we tackle these complexities by developing a finite element framework to study the diffusion-coupled growth and morphogenesis of finite bodies formed on uniform and flat substrates. We find that in this simplified growth setting, the evolving body exhibits a sequence of distinct growth stages that are reminiscent of natural systems, and appear spontaneously without any externally imposed regulation or coordination. The computational framework developed in this work can serve as the basis for future models that are able to account for growth in arbitrary geometrical settings, and can shed light on the basic physical laws that orchestrate growth and morphogenesis in the natural world.