论文标题
评估Mstali的精度和召回
Assessing the Precision and Recall of msTALI as Applied to an Active-Site Study on Fold Families
论文作者
论文摘要
蛋白质执行生物细胞所需的各种活动。此外，它们在结构上支持并支持重要的重要生物化学反应，这些反应在功能上是由活跃位置引起的。活跃位点是直接发生recc-tions和结合事件的区域。他们促进了亲特特的目的。描述功能关系取决于结合形成蛋白质的氨基酸的序列，结构和生物化学特性的因素。我们对主动站点描述的AP渗透是计算的，并且利用可用蛋白质数据的许多其他方法却没有理想。成功地识别功能相互作用是蛋白质注释和整个生物生物启动 - 马丁领域的进步。这项研究概述了我们的多结构扭转角对准（MSTALI）是通过将结果与其他现有方法进行比较来解决活动位点识别的合适策略。具体而言，我们解决了三个蛋白质家族中Mstali的精度。我们的靶蛋白是PDBIDS 1A2B，1B4V，1B8S，1COY，1CXZ，3COX，1D7E，1DPF，1F9I，1F9I，1FTN，1FTN，1IJH，1KOU，1KOU，1NWZ，1NWZ，1NWZ，2PHY和1SIC。
Proteins execute various activities required by biological cells. Further, they structurally support and pro-mote important biochemical reactions which functionally are sparked by active-sites. Active-sites are regions where reac-tions and binding events take place directly; they foster pro-tein purpose. Describing functional relationships depends on factors that incorporate sequence, structure, and the biochem-ical properties of amino acids that form proteins. Our ap-proach to active-site description is computational, and many other approaches utilizing available protein data fall short of ideal. Successful recognition of functional interactions is cru-cial to advancements in protein annotation and the bioinfor-matics field at large. This research outlines our Multiple Structure Torsion Angle Alignment (msTALI) as a suitable strategy for addressing active-site identification by comparing results to other existing methods. Specifically, we address the precision of msTALI across three protein families. Our target proteins are PDBIDs 1A2B, 1B4V, 1B8S, 1COY, 1CXZ, 3COX, 1D7E, 1DPF, 1F9I, 1FTN, 1IJH, 1KOU, 1NWZ, 2PHY, and 1SIC.
