论文标题
具有短期突触可塑性的广义半中心振荡器
Generalized half-center oscillators with short-term synaptic plasticity
论文作者
论文摘要
我们如何开发称为中央模式发生器（CPG）的小神经回路的简单但现实的模型，这有助于在活动物中产生复杂的多相运动？在本文中，我们介绍了一个全新的半中心振荡器（GHCO）的新模型（具有设计标准），即通过快速/慢抑制性和兴奋性突触相互耦合的神经元的（池），以产生交替的爆发或根据感官或其他外部输入或其他外部输入。我们还根据生理和功能标准以及分叉分析来展示如何校准其参数。该模型以生物状态合理的方式解释了短期神经调节，并且是开发更现实且功能精确的CPG模型的基础。示例和反例用于指出我们设计方法的一般性和有效性。
How can we develop simple yet realistic models of the small neural circuits known as central pattern generators (CPGs), which contribute to generate complex multi-phase locomotion in living animals? In this paper we introduce a new model (with design criteria) of a generalized half-center oscillator (gHCO), (pools of) neurons reciprocally coupled by fast/slow inhibitory and excitatory synapses, to produce either alternating bursting or synchronous patterns depending on the sensory or other external input. We also show how to calibrate its parameters, based on both physiological and functional criteria and on bifurcation analysis. This model accounts for short-term neuromodulation in a bio-physically plausible way and is a building block to develop more realistic and functionally accurate CPG models. Examples and counterexamples are used to point out the generality and effectiveness of our design approach.
