论文标题
能源成本在准确性，敏感性，特异性，速度和T细胞外国和自我识别的作用中的作用
The Role of Energy Cost on Accuracy, Sensitivity, Specificity, Speed and Adaptation of T Cell Foreign and Self Recognition
论文作者
论文摘要
能源消耗在包括T细胞歧视过程在内的生物系统中的关键作用已通过各种方式进行了研究。 T细胞识别中涉及不同水平能量耗散的T细胞识别的动力学校对（KPR）会影响功能结果，例如错误率和特异性。在这项工作中，我们定量地研究了能量成本如何影响误差部分，灵敏度，特异性，动力学速度，而平均第一通道时间（MFPT）和适应误差。这些提供了充分理解T细胞动力学的背景。发现能量在系统中起着核心作用，旨在在我们的动力学方案下以最快的速度达到最小误差分数以及最大的灵敏度和特异性，而动力学参数的数值是特别选择的，但是这种条件可以通过不同的数据破坏。从将稳态近似（SSA）应用于与KPR相关的每个复合物的浓度评估（用于量化各种可观察物的浓度）开始，我们详细介绍了分析和数值结果。
The critical role of energy consumption in biological systems including T cell discrimination process has been investigated in various ways. The kinetic proofreading(KPR) in T cell recognition involving different levels of energy dissipation influences functional outcomes such as error rates and specificity. In this work, we study quantitatively how the energy cost influences error fractions, sensitivity, specificity, kinetic speed in terms of Mean First Passage Time(MFPT) and adaption errors. These provide the background to adequately understand T cell dynamics. It is found that energy plays a central role in the system that aims to achieve minimum error fractions and maximum sensitivity and specificity with the fastest speed under our kinetic scheme for which numerical values of kinetic parameters are specially chosen, but such a condition can be broken with varying data. Starting with the application of steady state approximation(SSA) to the evaluation of the concentration of each complex produced associated with KPR, which is used to quantify various observables, we present both analytical and numerical results in detail.
