论文标题
序列对联想聚合物液滴内部结构的序列影响
Sequence Effects on Internal Structure of Droplets of Associative Polymers
论文作者
论文摘要
我们使用了langevin动力学模拟短相关聚合物，并沿轮廓对称地放置了两个贴纸，以研究这些聚合物在凝结液滴中的组织对组织的主要序列的影响。我们观察到，凝结的液滴内部的贴纸簇的形状，大小和数量从单个圆柱纤维变为许多紧凑型簇，因为人们沿着链轮廓的贴纸位置变化。在远程石聚合物的液滴中观察到由于分子内向分子间关联的转化而导致的衰老，但对于其他关联聚合物的其他序列没有观察到。讨论了我们的结果与本质上无序蛋白质的冷凝物的相关性。
We used Langevin dynamics simulations of short associative polymers with two stickers placed symmetrically along their contour to study the effect of the primary sequence of these polymers on their organization inside condensed droplets. We observed that the shape, size and number of sticker clusters inside the condensed droplet change from a single cylindrical fiber to many compact clusters, as one varies the location of stickers along the chain contour. Aging due to conversion of intramoleclular to intermolecular associations was observed in droplets of telechelic polymers, but not for other sequences of associating polymers. The relevance of our results to condensates of intrinsically disordered proteins is discussed.
