论文标题
边界的三维细胞质钙传播
Three-dimensional cytoplasmic calcium propagation with boundaries
论文作者
论文摘要
Ca $^{2+} $在单元信号转导中起重要作用。它的细胞内传播是CA $^{2+} $信号的最基本过程，例如钙波和双信使系统。在这项工作中，通过数值模拟和平均场Ansatz，在两个情况下，通过磷酸化读取了Ca $^{2+} $的3维概率分布，并通过磷酸化进行了研究。 Ca $^{2+} $的分布的覆盖范围是在$μ$ m的数量级上找到的，这与实验性观察到的钙尖峰和波浪一致。我们的结果表明，双信使系统可能发生在ER-PM交界处，以获得极大的效率。还通过计算磷酸化的平均位置和自由CA $^{2+} $来讨论激酶的缓冲效果。结果有助于了解Ca $^{2+} $信号的机制。
Ca$^{2+}$ plays an important role in cell signal transduction. Its intracellular propagation is the most basic process of Ca$^{2+}$ signaling, such as calcium wave and double messenger system. In this work, with both numerical simulation and mean field ansatz, the 3-dimensional probability distribution of Ca$^{2+}$, which is read out by phosphorylation, is studied in two scenarios with boundaries. The coverage of distribution of Ca$^{2+}$ is found at an order of magnitude of $μ$m, which is consistent with experimental observed calcium spike and wave. Our results suggest that the double messenger system may occur in the ER-PM junction to acquire great efficiency. The buffer effect of kinase is also discussed by calculating the average position of phosphorylations and free Ca$^{2+}$. The results are helpful to understand the mechanism of Ca$^{2+}$ signaling.
