论文标题
循环挤出的有效模型预测染色体结构域
Effective Model of Loop Extrusion Predicts Chromosomal Domains
论文作者
论文摘要
主动的环截面机制被认为是负责巨兆巴大小结构域在染色体中结构的主要平衡机制。我们开发了一个模型，通过求解与挤出机运动相关的动力学方程来研究染色体纤维的动力学。通过平均沿链条的挤出机的位置，我们建立了一个有效的平衡模型，该模型能够仅基于挤出蛋白的位置来重现实验接触图。我们使用染色体片段的数值模拟评估了有效模型的质量，并将结果与显式 - 脱节器模型和实验数据进行了比较。
An active loop-extrusion mechanism is regarded as the main out--of--equilibrium mechanism responsible for the structuring of megabase-sized domains in chromosomes. We developed a model to study the dynamics of the chromosome fibre by solving the kinetic equations associated with the motion of the extruder. By averaging out the position of the extruder along the chain, we build an effective equilibrium model capable of reproducing experimental contact maps based solely on the positions of extrusion--blocking proteins. We assessed the quality of the effective model using numerical simulations of chromosomal segments and comparing the results with explicit-extruder models and experimental data.
