论文标题
下丘中的非线性响应特性：线性和非线性响应的常见声音依赖性
Nonlinear response properties in the inferior colliculus: Common sound-frequency dependence for linear and nonlinear responses
论文作者
论文摘要
在听觉中间脑收敛的主要中心的神经元，下丘丘（ICC）的中央核已显示出线性显着的接收场或线性和非线性显着感受场。在这项研究中，我们使用反向相关性来探测CAT ICC中单个神经元的线性和非线性响应特性。接受场显示刺激参数的区域，从而增强或抑制了尖峰活动，从而可以研究相互作用以处理复杂的声音。从麻醉猫的神经记录中获得了峰值反应，以响应动态移动波纹（DMR）刺激。 DMR声音包含振幅和频率调制，并允许系统地绘制神经偏好。刺激包膜的相关性优选地激发神经元可以通过尖峰触发的协方差映射。为DMR的包络计算了尖峰触发的平均值和 - 稳定性，分别为每个频率载体（范围为0-5.5八度）。这使得对声音信封的处理进行了研究，并能够在神经元的首选频率而不是其他频率上研究非线性是否更明显。我们发现，超过一半的神经元（n = 120）至少在一个频率载体下显示出显着的非线性响应特性。在神经元的最佳频率上，非线性是主导的。非线性偏好可以具有与线性偏好相同或相反的时间接收场图案（例如on-Off）。没有发现与其他神经特性（例如特征选择性，相锁定等）的关系。因此，这些非线性似乎与特定类型的神经元相关，而是ICC神经元所固有的，表明过滤特性范围多样。
Neurons in the main center of convergence in the auditory midbrain, the central nucleus of the inferior colliculus (ICC) have been shown to display either linear significant receptive fields, or both, linear and nonlinear significant receptive fields. In this study, we used reverse correlation to probe linear and nonlinear response properties of single neurons in the cat ICC. The receptive fields display areas of stimulus parameters leading to enhanced or inhibited spiking activity, and thus allow investigating the interplay to process complex sounds. Spiking responses were obtained from neural recordings of anesthetized cats in response to dynamic moving ripple (DMR) stimuli. The DMR sound contains amplitude and frequency modulations and allows systematically mapping neural preferences. Correlations of the stimulus envelope that preferably excite neurons can be mapped with the spike-triggered covariance. The spike-triggered average and -covariance were computed for the envelope of the DMR, separately for each frequency carrier (spanning a range of 0-5.5 octaves). This enables studying processing of the sound envelope, and to investigate whether nonlinearities are more pronounced at the neurons' preferred frequencies rather than at other frequencies. We find that more than half of the neurons (n=120) display significant nonlinear response properties at least at one frequency carrier. Nonlinearities are dominant at the neuron's best frequency. The nonlinear preferences can have either the same or opposite temporal receptive field pattern (e.g. on-off) as the linear preferences. No relationship to other neural properties such as feature-selectivity, phase-locking, or the like has been found. Thus, these nonlinearities do not seem to be linked to a specific type of neuron but to be inherent to ICC neurons indicating a diverse range of filtering characteristics.
