论文标题
SARS-COV-2感染的转录景观拆除了该病毒激活的致病途径，提出了独特的性别特异性差异，并预测了量身定制的治疗策略
Transcriptional landscape of SARS-CoV-2 infection dismantles pathogenic pathways activated by the virus, proposes unique sex-specific differences and predicts tailored therapeutic strategies
论文作者
论文摘要
严重的急性呼吸综合症冠状病毒2（SARS-COV-2）疾病（Covid-19）的出现对全球健康构成了严重威胁。由于尚无特定的治疗剂来控制疾病的进化，因此对SARS-COV-2诱导的致病机制有更深入的了解将有助于表征Covid-19的新目标。本研究确定了SARS-COV-2感染后原代人肺上皮改变的一组特定的生物途径，研究了2003年大流行的SARS-COV的比较。还将转录组谱被视为可能的新型治疗靶标，而抗签名扰动分析预测了控制疾病进展的潜在药物。其中，有丝分裂原激活的蛋白激酶激酶（MEK），丝氨酸 - 苏氨酸激酶（AKT），雷帕霉素（MTOR）的哺乳动物靶标和I Kappa B激酶（IKK）抑制剂已成为候选药物。最后，提出了可能是男性较高共同死亡率的特定性别差异。
The emergence of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) disease (COVID-19) has posed a serious threat to global health. As no specific therapeutics are yet available to control disease evolution, more in-depth understanding of the pathogenic mechanisms induced by SARS-CoV-2 will help to characterize new targets for the management of COVID-19. The present study identified a specific set of biological pathways altered in primary human lung epithelium upon SARS-CoV-2 infection, and a comparison with SARS-CoV from the 2003 pandemic was studied. The transcriptomic profiles were also exploited as possible novel therapeutic targets, and anti-signature perturbation analysis predicted potential drugs to control disease progression. Among them, Mitogen-activated protein kinase kinase (MEK), serine-threonine kinase (AKT), mammalian target of rapamycin (mTOR) and I kappa B Kinase (IKK) inhibitors emerged as candidate drugs. Finally, sex-specific differences that may underlie the higher COVID-19 mortality in men are proposed.
