论文标题
连续规模非牛顿粒子传输模型的血液流行病 - 实施和验证
Continuum Scale Non Newtonian Particle Transport Model for Haemorheology -- Implementation and Validation
论文作者
论文摘要
我们为碰撞参数以扩散通量公式提供了一个连续尺度的粒子传输模型，用于红细胞。该模型是在泡沫中实现的，在血液动力学模拟的框架中。现代机械流变模型被实施和测试。该模型可针对已知的分析解决方案进行验证，并显示出与高质量网格的良好一致性，并且在血管流量模拟中使用的典型网格良好一致。不同大小和时间尺度的仿真结果表明，红细胞的迁移确实发生在1 mm以下的小血管上的生理相关时间表上，而血细胞比容浓度则调节非牛顿粘度。该模型构成了多尺度方法的造血学方法的一部分，模型参数将使用多组分lattice-boltzmann方法从中尺度模拟得出。该代码（Haemofoam）可用于感兴趣的研究人员。
We present a continuum scale particle transport model for red blood cells following collision arguments in a diffusive flux formulation. The model is implemented in FOAM, in a framework for haemodynamics simulations. Modern mechanistic rheology models are implemented and tested. The model is verified against a known analytical solution and shows excellent agreement for high quality meshes and good agreement for typical meshes as used in vascular flow simulations. Simulation results for different size and time scales show that migration of red blood cells does occur on physiologically relevany timescales on small vessels below 1 mm and that the haematocrit concentration modulates the non-Newtonian viscosity. This model forms part of a multi-scale approach to haemorheology and model parameters will be derived from meso-scale simulations using multi-component Lattice-Boltzmann methods. The code, haemoFoam, is made available for interested researchers.
