论文标题
为什么大规模模式对于理解细胞内肌动蛋白波是必不可少的
Why A Large Scale Mode Can Be Essential For Understanding Intracellular Actin Waves
论文作者
论文摘要
在过去的十年中，细胞内肌动蛋白波因其在各种细胞功能中的重要作用而引起了很多关注，从运动到细胞因子。实验方法已经显着提高，并且可以在各种时空尺度上捕获肌动蛋白波的动力学。但是，相应的粗粒理论大多避免了这种多尺度现象的全部复杂性。从这个角度来看，我们专注于激活剂抑制剂类型的最小连续体模型，并突出了通常被忽略的质量保存的定性作用。具体而言，我们的兴趣是在存在大规模模式的情况下，由于质量保存和肌动蛋白波的不同行为而在大规模模式下的数学机理之间联系。
During the last decade, intracellular actin waves have attracted much attention due to their essential role in various cellular functions, ranging from motility to cytokinesis. Experimental methods have advanced significantly and can capture the dynamics of actin waves over a large range of spatio-temporal scales. However, the corresponding coarse-grained theory mostly avoids the full complexity of this multi-scale phenomenon. In this perspective, we focus on a minimal continuum model of activator-inhibitor type and highlight the qualitative role of mass-conservation, which is typically overlooked. Specifically, our interest is to connect between the mathematical mechanisms of pattern formation in the presence of a large-scale mode, due to mass-conservation, and distinct behaviors of actin waves.
