论文标题
武汉海鲜市场早期的五名患者的支气管肺泡灌洗液样品的HLA预测
HLA predictions from the bronchoalveolar lavage fluid samples of five patients at the early stage of the Wuhan seafood market COVID-19 outbreak
论文作者
论文摘要
我们正处于全球病毒大流行中，没有治愈且死亡率很高。人白细胞抗原（HLA）基因复合物在宿主免疫中起关键作用。我们预测了来自Covid-19-19的早期阶段的五名患者的支气管肺泡灌洗液样品制备的转录组测序数据中的HLA I和II等位基因。我们在五分之四的患者中发现了HLA-i等位基因A*24：02，这比南汉中国人口的预期频率高（17.2％）。差异在统计上是显着的，而p值小于$ 10^{ - 4} $。我们的分析结果可能有助于提供对疾病易感性的未来见解。
We are in the midst of a global viral pandemic, one with no cure and a high mortality rate. The Human Leukocyte Antigen (HLA) gene complex plays a critical role in host immunity. We predicted HLA class I and II alleles from the transcriptome sequencing data prepared from the bronchoalveolar lavage fluid samples of five patients at the early stage of the COVID-19 outbreak. We identified the HLA-I allele A*24:02 in four out of five patients, which is higher than the expected frequency (17.2%) in the South Han Chinese population. The difference is statistically significant with a p-value less than $10^{-4}$. Our analysis results may help provide future insights on disease susceptibility.
