论文标题
弧形颗粒的混合物诱导的膜形态与曲率相反
Membrane morphologies induced by mixtures of arc-shaped particles with opposite curvature
论文作者
论文摘要
生物膜由各种蛋白质形成，这些蛋白质会产生内向或向外膜曲率。在本文中，我们研究了由弧形颗粒的混合物与粗粒化建模和模拟引起的膜形态。颗粒与膜的内，凹面或外部，凸面结合，从而产生相反符号的膜曲率。我们发现，凸结构颗粒的小部分可以稳定膜小管的三向连接，如细胞内质网中的蛋白质lunapark所建议的那样。对于可比的凹形结合和凸结构颗粒的比较，我们观察到相同类型的颗粒线，以及这些粒线引起的凹槽和凸起的膜形态。颗粒的比对和分离是由间接的，膜介导的相互作用驱动的。
Biological membranes are shaped by various proteins that either generate inward or outward membrane curvature. In this article, we investigate the membrane morphologies induced by mixtures of arc-shaped particles with coarse-grained modeling and simulations. The particles bind to the membranes either with their inward, concave side or their outward, convex side and, thus, generate membrane curvature of opposite sign. We find that small fractions of convex-binding particles can stabilize three-way junctions of membrane tubules, as suggested for the protein lunapark in the endoplasmic reticulum of cells. For comparable fractions of concave-binding and convex-binding particles, we observe lines of particles of the same type, and diverse membrane morphologies with grooves and bulges induced by these particle lines. The alignment and segregation of the particles is driven by indirect, membrane-mediated interactions.
