论文标题
能源资源有限的生化振荡的设计原理
Design principles for biochemical oscillations with limited energy resources
论文作者
论文摘要
由于生化系统可能经常遭受有限的能源资源的损失，因此必须利用内部分子波动来诱导随机节奏，因此了解具有有限能量资源的生化系统的基本原理仍然是一个巨大的理论挑战，以保持相位准确性和相位敏感性。在这里，我们通过在分析和数值上得出一般生化模型的能源准确性和灵敏度准确性权衡关系来解决问题。我们发现，通过噪声引起的振荡，生化系统的消耗要低得多的能源成本，以保持几乎相等的效率以保持精确的过程，而当能源资源受到限制时，清楚地阐明了生存机制。此外，可以预测最佳的系统大小，即可以同时达到最高灵敏度和准确性，从而为设计有限的能源的生物网络设计提供了新的策略。
As biochemical systems may frequently suffer from limited energy resources so that internal molecular fluctuation has to be utilized to induce random rhythm, it is still a great theoretical challenge to understand the elementary principles for biochemical systems with limited energy resources to maintain phase accuracy and phase sensitivity. Here, we address the issue by deriving the energy accuracy and the sensitivity-accuracy trade-off relations for a general biochemical model, analytically and numerically. We find that, biochemical systems consume much lower energy cost by noise-induced oscillations to keep almost equal efficiency to maintain precise processes than that by normal oscillations, elucidating clearly the survival mechanism when energy resources are limited. Moreover, an optimal system size is predicted where both the highest sensitivity and accuracy can be reached at the same time, providing a new strategy for the design of biological networks with limited energy sources.
