论文标题
普im:一种快速的方法,其成本降低以大规模检测到COVID-19
Purim: a rapid method with reduced cost for massive detection of CoVid-19
论文作者
论文摘要
Covid-19在世界各地散布。大流行的迅速失败需要对人口进行大规模筛查,能够与负面病例分开。这样的清洁将释放生产力的流动。当前使用常见PCR(聚合酶链反应)方法和可用资源执行的测试速率和成本是迫使要测试的受试者的选择。确实,必须以宝贵的时间来单独检查每个人。此外,排除潜在的积极个体筛查会导致健康风险,限制病毒率蔓延的努力的广泛放缓以及随之而来的死亡率。我们提出了一种新的程序,该程序是通过统一重新采样的感染众多人物纯化的,简而言之,能够通过对关节标志的交叉相关分析来解开任何具有廉价筛选的大型候选样品。该程序可以揭示和检测大多数阴性患者,在大多数情况下,发现了第一个或几个次级测试中已经存在的几个阳性的身份。我们研究了感染概率功能的二维相关案例。还考虑了多维拓扑结构,缩放的普imm程序。广泛的Purim测试可能衡量和体重的流行程度:它们的结果可能在早期阶段确定焦点区域。假设有数百或数千名受试者,及时和成本的节省将是显着的。普里姆可能能够过滤预定的航班,学者接受,受欢迎的国际活动参与者。随着流行病扩张的倒数,普im结果的最佳扩展正在增长。因此,越早,越好。
The CoVid-19 is spreading pandemically all over the world. A rapid defeat of the pandemic requires carrying out on the population a mass screening, able to separate positive from negative cases. Such a cleaning will free a flow of productive population. The current rate and cost of testing, performed with the common PCR (polymerase chain reaction) method and with the available resources, is forcing a selection of the subjects to be tested. Indeed, each one must be examined individually at the cost of precious time. Moreover, the exclusion of potentially positive individuals from screening induces health risks, a broad slowdown in the effort to curb the viral spread, and the consequent mortality rates. We present a new procedure, the Purified by Unified Resampling of Infected Multitudes, in short Purim, able to untangle any massive candidate sample with inexpensive screening, through the cross-correlated analysis of the joint speciments. This procedure can reveal and detect most negative patients and in most cases discover the identity of the few positives already in the first or few secondary tests. We investigate the the two-dimensional correlation case in function of the infection probability. The multi-dimensional topology, the scaled Purim procedure are also considered. Extensive Purim tests may measure and weight the degree of epidemic: their outcome may identify focal regions in the early stages. Assuming hundreds or thousand subjects, the saving both in time and in cost will be remarkable. Purim may be able to filter scheduled flights, scholar acceptance, popular international event participants. The optimal extension of Purim outcome is growing as the inverse of the epidemia expansion. Therefore, the earlier, the better.