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Automating the calibration of the parameters of a control policy by means of global optimization requires quantifying a closed-loop performance function. As this can be impractical in many situations, in this paper we suggest a semi-automated calibration approach that requires instead a human calibrator to express a preference on whether a certain control policy is "better" than another one, therefore eliminating the need of an explicit performance index. In particular, we focus our attention on semi-automated calibration of Model Predictive Controllers (MPCs), for which we attempt computing the set of best calibration parameters by employing the recently-developed active preference-based optimization algorithm GLISp. Based on the preferences expressed by the human operator, GLISp learns a surrogate of the underlying closed-loop performance index that the calibrator (unconsciously) uses and proposes, iteratively, a new set of calibration parameters to him or her for testing and for comparison against previous experimental results. The resulting semi-automated calibration procedure is tested on two case studies, showing the capabilities of the approach in achieving near-optimal performance within a limited number of experiments.