论文标题
单核还是多核？对基于磁性颗粒光谱的生物测定的磁性纳米颗粒的迷你综述
Single-core Or Multi-core? A Mini Review on Magnetic Nanoparticles for Magnetic Particle Spectroscopy-based Bioassays
论文作者
论文摘要
磁颗粒光谱（MPS）是一项源自磁性颗粒成像（MPI）的技术，并作为许多生物学和生物医学应用的独立平台而繁荣发展，得益于磁性纳米颗粒（MNP）的便捷制备和化学修饰。近年来，已在广泛的文献中报道了MPS作为一种多功能平台，用于使用人工设计的MNP，用于不同的生物测定目的，其中MNP用作磁性示踪剂，表面功能化试剂（例如，抗体，Aptamers，Aptamers，peptides等）以及从生物素中捕获生物分析的小探测器。 MNP表面上的生化复合物可以针对不同的生物测定要求进行量身定制，而MNP的设计对基于MPS的生物测定的关注较少。对于大多数生物测定应用中的MNP，超级磁性是避免团聚和假磁信号的先决条件。单核和多核超磁纳米颗粒（SPMNP）普遍用于基于MPS的生物测定中。在这篇迷你综述中，我们比较了分别用单核纳米颗粒来实现基于体积和表面的生物测定的不同MPS平台的利弊。
Magnetic particle spectroscopy (MPS) is a technology that derives from magnetic particle imaging (MPI) and thrives as a standalone platform for many biological and biomedical applications, benefiting from the facile preparation and chemical modification of magnetic nanoparticles (MNPs). In recent years, MPS has been reported in extensive literatures as a versatile platform for different bioassay purposes using artificially designed MNPs, where the MNPs serve as magnetic tracers, the surface functionalized reagents (e.g., antibodies, aptamers, peptides, etc.) and tiny probes capturing target analytes from biofluid samples. The biochemical complexes on MNP surfaces can be tailored for different bioassay requirements, while the design of MNPs are of less attention for MPS-based bioassays. For MNPs in most bioassay applications, superparamagnetism is prerequisite to avoid agglomerates and false magnetic signals. Single- and multi-core superparamagnetic nanoparticles (SPMNPs) are prevalently used in MPS-based bioassays. In this mini review, we compared the pros & cons of different MPS platforms realizing volumetric- and surface-based bioassays with single- and multi-core nanoparticles, respectively.
