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This paper focuses on a new path division multiple access (PDMA) for both uplink (UL) and downlink (DL) massive multiple-input multiple-output network over a high mobility scenario, where the orthogonal time frequency space (OTFS) is adopted. First, the 3D UL channel model and the received signal model in the angle-delay-Doppler domain are studied. Secondly, the 3D-Newtonized orthogonal matching pursuit algorithm is utilized for the extraction of the UL channel parameters, including channel gains, directions of arrival, delays, and Doppler frequencies, over the antenna-time-frequency domain. Thirdly, we carefully analyze energy dispersion and power leakage of the 3D angle-delay-Doppler channels. Then, along UL, we design a path scheduling algorithm to properly assign angle-domain resources at user sides and to assure that the observation regions for different users do not overlap over the 3D cubic area, i.e., angle-delay-Doppler domain. After scheduling, different users can map their respective data to the scheduled delay-Doppler domain grids, and simultaneously send the data to base station (BS) without inter-user interference in the same OTFS block. Correspondingly, the signals at desired grids within the 3D resource space of BS are separately collected to implement the 3D channel estimation and maximal ratio combining-based data detection over the angle-delay-Doppler domain. Then, we construct a low complexity beamforming scheme over the angle-delay-Domain domain to achieve inter-user interference free DL communication. Simulation results are provided to demonstrate the validity of our proposed unified UL/DL PDMA scheme.