论文标题
巨型巨型，单层囊泡的自组装
Bulk self-assembly of giant, unilamellar vesicles
论文作者
论文摘要
为基础科学和应用创建类似细胞的模型的愿望促使人们竭尽全力创建巨大的Unilamellar囊泡（GUVS）。但是，在批量上选择性地组装GUV的途径仍然难以捉摸。在散装溶液中，膜形成的分子，例如磷脂，单尾表面活性剂和阻断共聚物通常会自组装成多层洋葱样结构。因此，尽管自组装过程可以形成纳米级单层囊泡，但需要用液滴或表面脚手架才能创建GUV。在这里，我们表明，令人惊讶的是，与其他囊泡拓扑相比，具有几乎完全选择性的自组装细胞大小的GUV可以进行。看似矛盾的一对功能，使这似乎在纳米级具有非常动态的分子，从而产生异常刚性的膜。所得的自组装途径可以封装分子和胶体，还可以生成可以生长和分裂的模型原始细胞。
The desire to create cell-like models for fundamental science and applications has spurred extensive effort towards creating giant unilamellar vesicles (GUVs). However, a route to selectively self-assemble GUVs in bulk has remained elusive. In bulk solution, membrane-forming molecules such as phospholipids, single-tailed surfactants, and block copolymers typically self-assemble into multilamellar, onion-like structures. So although self-assembly processes can form nanoscale unilamellar vesicles, scaffolding by droplets or surfaces is required to create GUVs. Here we show that surprisingly, it is possible to bulk self-assemble cell-sized GUVs with almost complete selectivity over other vesicle topologies. The seemingly paradoxical pair of features that enables this appears to be having very dynamic molecules at the nanoscale, that create unusually rigid membranes. The resultant self-assembly pathway enables encapsulation of molecules and colloids, and can also generate model primitive cells that can grow and divide.
