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In emerging applications such as blockchains and collaborative data analytics, there are strong demands for data immutability, multi-version accesses, and tamper-evident controls. This leads to three new index structures for immutable data, namely Merkle Patricia Trie (MPT), Merkle Bucket Tree (MBT), and Pattern-Oriented-Split Tree (POS-Tree). Although these structures have been adopted in real applications, there is no systematic evaluation of their pros and cons in the literature. This makes it difficult for practitioners to choose the right index structure for their applications, as there is only a limited understanding of the characteristics of each index. To alleviate the above deficiency, we present a comprehensive analysis of the existing index structures for immutable data, evaluating both their asymptotic and empirical performance. Specifically, we show that MPT, MBT, and POS-Tree are all instances of a recently proposed framework, dubbed \my{Structurally Invariant and Reusable Indexes (SIRI)}. We propose to evaluate the SIRI instances based on five essential metrics: their efficiency for four index operations (i.e., lookup, update, comparison, and merge), as well as their \my{deduplication ratios} (i.e., the size of the index with deduplication over the size without deduplication). We establish the worst-case guarantees of each index in terms of these five metrics, and we experimentally evaluate all indexes in a large variety of settings. Based on our theoretical and empirical analysis, we conclude that POS-Tree is a favorable choice for indexing immutable data.