论文标题
使用3D语义分割卷积神经网络在常规CT成像中的完全自动化的身体组成分析
Fully-automated Body Composition Analysis in Routine CT Imaging Using 3D Semantic Segmentation Convolutional Neural Networks
论文作者
论文摘要
人体组织组成是一种已知的生物标志物,在心血管,肿瘤和骨科疾病中具有高诊断和预后价值,但也用于康复医学或药物剂量。在这项研究中,目的是从腹部的标准CT检查中开发完全自动化,可重现和定量的3D体积,以便能够作为常规临床成像的一部分提供此类有价值的生物标志物。因此,在每个第五个轴向切片中完全注释了40 CT的内部数据集和10个用于测试的CT,具有五个不同的语义体区域:腹腔,骨骼,肌肉,肌肉,皮下组织和胸腔腔。多分辨率U-NET 3D神经网络用于分割这些身体区域,然后使用已知的Hounsfield单位限制进行亚分类脂肪组织和肌肉。在所有语义区域中平均的Sørensen骰子得分为0.9553,亚分类组织的类内相关系数高于0.99。我们的结果表明,对常规CT成像的完全自动化的身体组成分析可以在整个腹部中提供稳定的生物标志物,而不仅仅是L3切片,这是从历史上看,这是分析临床常规中身体组成的参考位置。
Body tissue composition is a long-known biomarker with high diagnostic and prognostic value in cardiovascular, oncological and orthopaedic diseases, but also in rehabilitation medicine or drug dosage. In this study, the aim was to develop a fully automated, reproducible and quantitative 3D volumetry of body tissue composition from standard CT examinations of the abdomen in order to be able to offer such valuable biomarkers as part of routine clinical imaging. Therefore an in-house dataset of 40 CTs for training and 10 CTs for testing were fully annotated on every fifth axial slice with five different semantic body regions: abdominal cavity, bones, muscle, subcutaneous tissue, and thoracic cavity. Multi-resolution U-Net 3D neural networks were employed for segmenting these body regions, followed by subclassifying adipose tissue and muscle using known hounsfield unit limits. The Sørensen Dice scores averaged over all semantic regions was 0.9553 and the intra-class correlation coefficients for subclassified tissues were above 0.99. Our results show that fully-automated body composition analysis on routine CT imaging can provide stable biomarkers across the whole abdomen and not just on L3 slices, which is historically the reference location for analysing body composition in the clinical routine.