论文标题
从几何形状中推断上皮组织的流动特性
Inferring the flow properties of epithelial tissues from their geometry
论文作者
论文摘要
无定形材料表现出具有强烈非线性行为的复杂材料。低于屈服应力,它们以塑料固体的形式行为,而它们开始屈服于临界应力$σ_c$。但是,控制可塑性的关键数量很难测量,是弱点的密度$ p(x)$,其中$ x $是本地塑料故障所需的额外压力。在热力学限制中,$ p(x)\ sim x^θ$在$ x = 0 $的$ x = 0 $下,在屈服应力$σ_c$下方。这种奇异性与塑料事件的Spannig雪崩的存在有关。在这里,我们解决了一个问题,是否可以仅靠呈孢子结构的几何形状来确定弱点的密度和材料的流量。我们表明,组织中细胞包装的顶点模型表现出塑料无定形系统的现象学。随着屈服应力从上方接近,应变率消失,雪崩尺寸$ s $及其持续时间$τ$差异。然后,我们表明,通常在能量功能取决于拓扑的材料中,值$ x $与在塑料事件中消失的债券的长度$ l $成正比。因此,对于这类型号,$ P(x)$仅从几何形状就可以很容易地测量。将这种方法应用于果蝇发育中的机翼上皮中细胞堆积几何形状的定量,我们发现在该组织中,$ p(l)$具有幂律,其指数类似于在其固体相中为顶点模型发现的数字发现的指数。这表明该组织表现出从集体细胞行为中出现的可塑性和非线性物质特性,并且这些材料特性控制了发育过程。我们基于拓扑和能量学之间关系的方法提出了与屈服过渡相关的杰出问题的新途径。
Amorphous materials exhibit complex material proprteties with strongly nonlinear behaviors. Below a yield stress they behave as plastic solids, while they start to yield above a critical stress $Σ_c$. A key quantity controlling plasticity which is, however, hard to measure is the density $P(x)$ of weak spots, where $x$ is the additional stress required for local plastic failure. In the thermodynamic limit $P(x)\sim x^θ$ is singular at $x= 0$ in the solid phase below the yield stress $Σ_c$. This singularity is related to the presence of system spannig avalanches of plastic events. Here we address the question if the density of weak spots and the flow properties of a material can be determined from the geometry of an amporphous structure alone. We show that a vertex model for cell packings in tissues exhibits the phenomenology of plastic amorphous systems. As the yield stress is approached from above, the strain rate vanishes and the avalanches size $S$ and their duration $τ$ diverge. We then show that in general, in materials where the energy functional depend on topology, the value $x$ is proportional to the length $L$ of a bond that vanishes in a plastic event. For this class of models $P(x)$ is therefore readily measurable from geometry alone. Applying this approach to a quantification of the cell packing geometry in the developing wing epithelium of the fruit fly, we find that in this tissue $P(L)$ exhibits a power law with exponents similar to those found numerically for a vertex model in its solid phase. This suggests that this tissue exhibits plasticity and non-linear material properties that emerge from collective cell behaviors and that these material properties govern developmental processes. Our approach based on the relation between topology and energetics suggests a new route to outstanding questions associated with the yielding transition.