论文标题
GEANT4使用MO-92标记的延迟γ光谱对新范围验证方法进行模拟
GEANT4 simulation of a new range verification method using delayed gamma spectroscopy of a Mo-92 marker
论文作者
论文摘要
在这项工作中，我们提出了一种用于体内质子治疗范围验证的新技术。该技术利用了一个小的强子肿瘤标记物，$^{92} $ MO，在距临床治疗量的已知距离很短的距离处植入。在处理过程中从标记中发出的信号可以直接测量标记位置的质子束能。质子束和标记核之间的融合蒸发反应导致延迟特征$γ$射线的发射，该射线被检测到，以改善信噪比。为了确定此技术的生存能力并为将来的工作建立实验设置，将Monte Carlo Package Geant4与Root结合使用，以模拟治疗方案，并使用此工作中概述的新方法。这些模拟表明，分析由竞争反应产生的延迟$γ$射线的强度可准确地测量质子束相对于标记的范围，并具有亚毫米不确定性。
In this work, we propose a novel technique for in-vivo proton therapy range verification. This technique makes use of a small hadron tumour marker, $^{92}$Mo, implanted at a short known distance from the clinical treatment volume. Signals emitted from the marker during treatment can provide a direct measurement of the proton beam energy at the marker's position. Fusion-evaporation reactions between the proton beam and marker nucleus result in the emission of delayed characteristic $γ$ rays, which are detected off-beam for an improved signal-to-noise ratio. In order to determine the viability of this technique and to establish an experimental setup for future work, the Monte Carlo package GEANT4 was used in combination with ROOT to simulate a treatment scenario with the new method outlined in this work. These simulations show that analyzing the intensity of delayed $γ$ rays produced from competing reactions yields a precise measurement of the range of the proton beam relative to the marker, with sub-millimeter uncertainty.
