论文标题
超快功能磁共振成像揭示了神经塑性驱动的时机调制
Ultrafast functional magnetic resonance imaging reveals neuroplasticity-driven timing modulations
论文作者
论文摘要
功能磁共振成像（fMRI）主要利用用于沿分布式途径的空间映射激活灶。但是，解决激活序列的动态信息仍然难以捉摸。在这里，我们显示了一种超快速fMRI（UFMRI）方法 - 一种促进的非侵入性方法，用于绘制具有高时空敏感性和分辨率高的分布式途径中的血氧水平依赖性（BOLD）响应时间。在正常和黑暗饲养条件下研究了小鼠视觉途径。结果表明，正常饲养小鼠的大胆反应可保留从发作到峰值时间的神经输入顺序。但是，由于较黑饲养而引起的皮质反应的调节效应仅在早期响应时机下可测量，而在以后的时间安排则测量响应的一般延迟。我们的发现突出了强有力测量早期大胆时机的重要性，并为在健康和异常条件下更好地理解和解释功能MRI铺平了道路。
Functional Magnetic Resonance Imaging (fMRI) is predominantly harnessed for spatially mapping activation foci along distributed pathways. However, resolving dynamic information on activation sequence remains elusive. Here, we show an ultra-fast fMRI (ufMRI) approach - a facilitating non-invasive methodology for mapping Blood-Oxygenation-Level-Dependent (BOLD) response timings in distributed pathways with high spatiotemporal sensitivity and resolution. The mouse visual pathway was investigated under both normal and dark reared conditions. Results show that BOLD responses of normal reared mice preserve the neural input order from onset to peak times. However, modulatory effects in cortical responses due to dark rearing are only measurable at early response timings while a general delay in responses is measured at later timings. Our findings highlight the importance of robustly measuring early BOLD timings and pave the way for a better understanding and interpretation of functional MRI in healthy and aberrant conditions.
